The Medical College - Page 52
Figure 3
Effect of GMP-140 pretreatment on the binding of
neutrophils
to cultured endothelial cells.
Prior to the assay, aliquots of either
neutrophils or endothelial
cells were incubated with GMP-140 and
subsequently washed
by centrifugation. For the assay, pretreated
neutrophils were
mixed with untreated endothelial cells
(q) or untreated
neu-
trophils were mixed with treated endothelial
cells (s).
184.
As the concentration of GMP-140 used to
coat
plastic dishes was increased:
A.
the number of neutrophils attaching to
the
plastic tended to increase.
B.
the number of neutrophils attaching to
the
plastic tended to decrease.
C.
the tightness of binding of neutrophils
to
the plastic tended to increase.
D.
the tightness of binding of neutrophils
to
the plastic tended to decrease.
185.
Plastic dishes that were not coated with
GMP-
140:
A.
did not bind monocytes.
B.
allowed attachment of about
1 /4 of the
monocytes.
C.
allowed attachment of about
1 /2 of the
monocytes.
D.
allowed attachment of most of the
mono-
cytes.
186.
Coating of plastic dishes with
GMP-140:
A.
caused the largest increase in binding
of
neutrophils.
B.
caused the largest increase in the binding
of
lymphocytes.
C.
caused the largest increase in the binding
of
monocytes.
D.
caused approximately equal increases
in
binding of all cells.
187.
The data presented:
A.
strongly support the hypothesis that
neu-
trophils bind to GMP-140 on the surface
of
endothelial cells.
B.
strongly support the hypothesis that
neu-
trophils use GMP-140 on the
neutrophil
surface to attach to endothelial
cells.
C.
strongly refute the hypothesis that
neu-
trophils bind to GMP-140 on the surface
of
endothelial cells.
D.
strongly refute the hypothesis that
neu-
trophils use GMP-140 on the
neutrophil
surface to attach to endothelial
cells.
188.
The data presented:
A.
strongly support the hypothesis that
neu-
trophils bind to CD-18 on the surface
of
endothelial cells.
B.
strongly support the hypothesis that
neu-
trophils use CD-18 on the neutrophil
sur-
face to attach to endothelial
cells.
C.
strongly refute the hypothesis that
neu-
trophils bind to CD-18 on the surface
of
endothelial cells.
D.
strongly refute the hypothesis that
neu-
trophils use CD-18 on the neutrophil
sur-
face to attach to endothelial
cells.
189.
Based on the data and information presented,
a
human patient who had a genetic defect that
pre-
vented synthesis of GMP-140 would
probably
be most severely impaired in:
A.
phagocytosis of bacteria.
B.
killing of virus-infected cells by
natural
killer cells.
C.
cell-mediated immune responses to
most
targets.
D.
humoral immune responses to most
targets.
Passage VIII (Questions
190–194)
Enzymes have often been referred to as
biological
catalysts. They have many properties in common
with
other catalysts.
190.
Enzymes are generally:
A.
carbohydrates.
C.
lipids.
B.
proteins.
D.
nucleic acids.
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